In an act of revenge against Spider-Man for the death of Spencer Smythe, Alistair Smythe created his version of "Spider-Slayers". He unleashed several slayers which included a small arachnid that worked as a tracking device, a six-tentacled amoeboid, a towering humanoid slayer with multiple personality disorder, a black widow, tarantula, and a scorpion. Alistair constructed several of the slayers with the "assistance" of inmates he liberated from a private sanitarium, goading Spider-Man into several battles that inadvertently involved others such as Scorpion (Mac Gargan) and Black Cat.