Caesar Cicero was a member of Silvermane's Maggia family. He hoped to replace Silvermane as head of the family one day. He bailed out Louis Wilson to help Silvermane decipher the Lifeline Tablet.
Spider-Man read about it and tried to capture Big C, but he managed to flee from his office, taking with him Martha and Billy Connors to have Curt Connors assist Wilson in cracking the tablet's secret code.
When Silvermane drank the elixir of life, made with the tablet's formula, Big C tried to convince Man Mountain Marko that the young man was an impostor, but the arrival of Spider-Man and Lizard forced him to flee the Galby Building.